Back to search page

TOES20210120003

New biomaterial for bone tissue regeneration

TECHNOLOGY PROFILE   OFFER   ADD TO FAVOURITES

 

ABSTRACT

Researchers from a Spanish University have developed a new biomaterial for bone lesions treatment based on sea cucumbers and an in vitro method of preparing it. It is highly biocompatible and exhibits in vivo functionality with potentially better results in terms of bone regeneration and repair than other currently available materials. The university is looking for partners from the pharma / health industry interested in licensing this patented technology.

 

PROFILE IMAGES


FULL DESCRIPTION

Hard tissue injuries, especially bone injuries, are very difficult to treat due to their special biological and functional characteristics. Most of the biomaterials currently available for the treatment of bone injuries have a poor biocompatibility and functionality in vivo and to date, the treatments and materials used in severe injuries to human bone result in very slow biointegration in the bone and low success rates. Therefore, the search for new highly biocompatible materials for use in the repair of bone defects is a priority in the field of trauma medicine research.

Researchers from a Spanish have developed a process for obtaining and using a new biomaterial employing for the first time dermal ossicles from Sea cucumbers (Holothuria echinoderm). These calcified microstructures are synthesized by one or more cells of the animal, which adhere closely to the surface of the ossicle. This makes the surface of the ossicles potentially highly biocompatible, which supports its clinical use as an inducing agent for bone regeneration.

The results obtained from the ex vivo and in vivo biocompatibility and efficacy studies have confirmed the proper biointegration process of the biomaterial, with the absence of signs of necrosis, tumor, infection, hemorrhage or rejection. Furthermore, greater bone repair and regeneration have been demonstrated in bone defects treated with holothurian ossicles.

The university is looking for partners from the pharma / health industry interested in licensing this patented technology.


Partner expertise sought:

- Specific area of activity of the partner: The University is looking for companies involved in regenerative medicine, tissue engineering or cell therapy, in order to reach a license agreement.


Advantages & innovations:

Highly biocompatible material. Cell adhesion to the surface of the ossicle in holothuria supports its biocompatibility and its use as an inducing agent for bone regeneration without inflammation or detectable adverse effects.
Potentially useful for in vivo regeneration. Hard tissues, especially bone, are difficult to treat and most biomaterials currently have poor functionality in vivo.
Better bone regeneration results than other available materials.
Optimum porosity and roughness conditions to be used in regenerative medicine.
Material available in nature. As fishery by-products, holothuria dermal ossicles used as raw materials are versatile elements, easy to handle and available at a low cost.


Development Stage:

Under development/lab tested


IPR:

Patent(s) applied for but not yet granted - Spanish patent applied with priority date 15/12/2020, therefore possibility of international PCT or European patent extension.

Sign-in or create an account

To express an interest in this profile, you must first sign in or create a new account.

If you already have an account, sign in here

Not got an account yet, sign up here

KEY INFORMATION

Country of origin
SPAIN
Date created
20/01/2021
Date updated
22/01/2021
Deadline
22/01/2022

PARTNERSHIP(S) SOUGHT

License agreement

CLASSIFICATIONS

INDUSTRY SECTORS
Paper, Pulp, Textiles, Leather and Footwear \ Medicine and Health \ Life Sciences \ Big drug delivery client
TECHNOLOGY KEYWORDS
BIOLOGICAL SCIENCES / Medicine, Human Health / Medical Technology / Biomedical Engineering / BIOLOGICAL SCIENCES / Medicine, Human Health / Medical Biomaterials
COMMERCIAL KEYWORDS
none...
MARKET KEYWORDS
MEDICAL/HEALTH RELATED / Clinical Medicine / Orthopaedics / MEDICAL/HEALTH RELATED / Anatomy, Pathology, Immunology, Physiology / MEDICAL/HEALTH RELATED / Agro and Marine biotech / Marine products
A2020